The overall objective of this research group is to provide the scientific basis and technological means to understand how occupational diseases are induced by exposure to chemical substances and other hazardous factors in the workplace. Research is conducted mainly based on laboratory experiments, focusing on the mechanisms of poisoning due to chemical substances including the interaction with individual traits of workers, e.g. sex, age and genetics. Another objective is the development of biomarkers, i.e. monitoring tools for the early detection of hazard exposure and adverse health effects.