| 1942 | The Research Institute of Industrial Safety (RIIS) was founded in Tokyo by the Ministry of Welfare |
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| 1943 | Annexed as the Industrial Safety Exhibition Center |
| 1947 | Transferred to the Japanese Ministry of Labour |
| 1961 | Annexed as the Industrial Safety Exhibition Center in Osaka |
| 1966 | Branch laboratories were established in Kiyose, Tokyo |
| 1971 | Reconstruction of the headquarters building |
| 1992 | Completion of a new headquarters building with a material and new technology laboratory in Kiyose, and integration with the laboratory |
| 1995 | The English name was changed from "Research Institute of Industrial Safety (RIIS) " to "National Institute of Industrial Safety (NIIS) " |
| 2001 | The institute was transferred to the Japanese Ministry of Health, Labour and Welfare |
| 2001 | The Institute became an independent administrative institution |
| 2006 | The NIIS and NIIH were amalgamated to become the National Institute of Occupational Safety and Health |
| 1949 | The Silicosis Laboratory (KEIHAISHIKENSHITU) was founded in Kinugawa, Tochigi Prefecture, as an institution attached to the Division of Occupational Safety and Health, Ministry of Labour, at the same location as the Kinugawa Silicosis Hospital |
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| 1956 | In accordance with the Ministry of Labour Organization Act, the forerunner of the National Institute of Industrial Health (NIIH, the ROUDO EISEI KENKYUSHO), was established in Nakahara-ku, Kawasaki, Kanagawa Prefecture |
| 1963 | An international scientific journal entitled “INDUSTRIAL HEALTH” was first published |
| 1964 | The National Institute of Industrial Health (SANGYOU IGAKU SOUGOU KENKYUSHO) was opened in Tama-ku, Kawasaki City |
| 1977 | The WHO Collaborating Center for Occupational Health was introduced |
| 1990 | Emperor Akihito visited the NIIH |
| 2000 | The Final Report entitled “Occupational Health Research Strategies in the 21st Century” was published by the Ministry of Labour |
| 2001 | The Institute was transferred into the new Ministry of Health, Labour and Welfare |
| 2001 | The Institute became an independent administrative institution, and the “National Conference on the Promotion of Occupational Health Priority Research” was organized |
| 2003 | The NIIH International Center was founded |
| 2006 | The NIIH and NIIS were amalgamated to become the National Institute of Occupational Safety and Health |